Expression of CD55 and CD59 in chronic rhinosinusitis and its significance.
- Author:
Lei XIA
1
;
Yinfeng WANG
2
;
Wei GAO
1
;
Hong GAO
1
Author Information
- Publication Type:Journal Article
- MeSH: CD55 Antigens; metabolism; CD59 Antigens; metabolism; Female; Flow Cytometry; Humans; Rhinitis; metabolism; Sinusitis; metabolism
- From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2014;49(12):1021-1023
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo understand the expression of complement regulatory proteins CD55 and CD59, which secreted by epithelial cells of normal and chronic sinusitis patients.
METHODSCell culture and flow cytometry were used to detect the expression of complement regulatory proteins CD55 and CD59.SPSS 18.0 software was used to analyze the data.
RESULTSCD55 was expressed both in normal nasal mucosa and mucosa of chronic sinusitis. The expression in normal group was 0.001 ± 0.001, significantly lower than that in CRS group which was 0.067 ± 0.028 (t = -10.535, P < 0.01). CD59 was also expressed in the two groups . In normal group, the expression of CD59 was 0.879 ± 0.005, significantly higher than that in CRS group which was 0.238 ± 0.034 (t = 83.416, P < 0.01).
CONCLUSIONSThe nasal mucosa in CRS patients showed low expression of CD55 and high expression of CD59. This mechanism may be involved in the occurrence of CRS.
