Expression of CD55 and CD59 in chronic rhinosinusitis and its significance

VernacularTitle:CD55和CD59在慢性鼻-鼻窦炎中的表达及意义
Author: Lei XIA ¹ ; Yinfeng WANG ; Wei GAO ; Hong GAO
Author Information

1. 安徽医科大学附属省立医院耳鼻咽喉头颈外科
Keywords: Sinusitis; Antigen,CD55; Antigen,CD59; Flow cytometry
From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2014;49(12):1021-1023
CountryChina
Language:Chinese
Abstract: Objective To understand the expression of complement regulatory proteins CD55 and CD59,which secreted by epithelial cells of normal and chronic sinusitis patients.Methods Cell culture and flow cytometry were used to detect the expression of complement regulatory proteins CD55 and CD59.SPSS 18.0 software was used to analyze the data.Results CD55 was expressed both in normal nasal mucosa and mucosa of chronic sinusitis.The expression in normal group was 0.001 ±0.001,significantly lower than that in CRS group which was 0.067 ± 0.028 (t =-10.535,P ＜ 0.01).CD59 was also expressed in the two groups.In normal group,the expression of CD59 was 0.879 ± 0.005,significantly higher than that in CRS group which was 0.238 ± 0.034 (t =83.416,P ＜0.01).Conclusions The nasal mucosa in CRS patients showed low expression of CD55 and high expression of CD59.This mechanism may be involved in the occurrence of CRS.