Selective CoX-2 inhibitor, non- steroidal anti-inflammatory drugs
- Author:
Phan Van Dao
- Publication Type:Journal Article
- Keywords:
drug
- MeSH:
Anti-Inflammatory Agents, Non-Steroidal;
Pharmaceutical Preparations;
Cyclooxygenase 2 Inhibitors
- From:Journal of Medical Research
1998;7(3):40-44
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
CoX-2 or prostaglandin GH synthetase-2 is an enzyme which has induction, especially in the inflamatory reactions. The inflamatory stimulations activate the CoX-2 of monocytes, macrophages, cells of synovial membrane to synthesize prostaglandin which induce the inflamatory reactions. The non- steroid anti- inflamatory drugs inhibit the CoX-2 so they have anti- inflamatory effects. However, they also inhibit CoX-1 which induce some side effects such as gastrointestinal and kidney accidents, haemorrhage and hypersensitivities. The selective CoX-2 inhibitors have some properties: long half elimination life, easier uptake by oral; the same pharmacokinetics in both elderly and children and uncommon side effects (0.1 -1% treated cases).
