Low expression of succinate dehydrogenase subunit B in locally recurrent nasopharyngeal carcinoma and implication for prognosis
10.3760/cma.j.issn.1673-0860.2015.01.009
- VernacularTitle:琥珀酸脱氢酶B在局部复发鼻咽癌组织中的低表达及其与预后的关系
- Author:
Sen LIN
1
;
Zhijian DAI
;
Chongxi CHEN
;
Shenghua PAN
;
Zhisu LIAO
Author Information
1. 温州医科大学附属第三医院耳鼻咽喉科
- Keywords:
Nasopharyngeal neoplasms;
Succinate dehydrogenase;
Prognosis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2015;50(1):38-42
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of succinate dehydrogenase subunit B(SDHB) in the tissues of locally recurrent nasopharyngeal carcinoma (rNPC) and the correlation with the clinicopathological factors and prognosis of rNPC.Methods Immunohistochemistry was used to detect the expression of SDHB in the tissues of primary and locally recurrent nasopharyngeal carcinoma.The relationship between SDHB expression and clinicopathological features was analyzed using the Chi-square test,and Kaplan-Meier method and Log-rank test were used for survival analysis.The independent prognostic factors of rNPC were analyzed by Cox regression model.Results Low SDHB expression was showed in 76.5％ (39/51) of the patients with rNPC,significantly higher than 57.1％ (24/42) of primary nasopharyngeal carcinoma (x2 =4.098,P ＜ 0.05).Low expression of SDHB strongly was correlated with T classification,clinical stage and cranial nerve palsy.Patients with low SDHB expression had a shorter survival time and a lower 3 or 5 year survival rate compared to the patients with high SDHB expression.Multivariate analysis showed that low SDHB expression was an independent predictor for overall survival of patients with rNPC (P ＜ 0.05).Conclusion The low SDHB expression is an independent indicator for poor prognosis of rNPC and may play an important role in the recurrence of rNPC.
