Efficiency of (99)Tc(m)-sestamibi in diagnosis of parathyroid diseases with primary hyperparathyroidism.
- Author:
Bojun WEI
1
;
Hong SHEN
2
;
Guansheng TONG
2
;
Rengui WANG
2
;
Hong CHANG
2
Author Information
- Publication Type:Journal Article
- MeSH: Adenoma; Carcinoma; Humans; Hyperparathyroidism, Primary; diagnosis; Hyperplasia; Parathyroid Glands; Parathyroid Neoplasms; Parathyroidectomy; Radiopharmaceuticals; Reproducibility of Results; Technetium Tc 99m Sestamibi; Thyroid Nodule
- From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2015;50(2):123-126
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficiency of (99)Tc(m)-sestamibi (MIBI) in the diagnosis of parathyroid diseases with primary hyperparathyroidism.
METHODSOne hundred and four cases with primary hyperparathyroidism underwent MIBI and parathyroidectomy between May 2010 to November 2013 were reviewed. With MIBI, single adenoma was found in 91 cases, two adenomas in 5 cases, carcinoma and hyperplasia in 3 cases respectively. Primary hyperparathyroidism was diagnosed based on the associated symptoms and signs in 93 patients, while it was indicated in 11 asymptomatic patients due to the presence of hypercalcemia in health examination. Parathroid hormone levels ranged from 98 to 2 800 ng/L, and serum calcium levels were between 2.56-4.23 mmol/L.
RESULTSThe sensitivity of MIBI for total diseased parntyroids was 84.0% (100/119), and that for parathyroid adenoma, parnthyroid carcinoma, atypical adenoma and primary parathyroid hyperplasia was 87.1% (88/101), 3/3, 2/2 and 7/13, respectively.
CONCLUSIONSMIBI is efficient in the diagnosis of parathyroid diseases with primary hyperparathyroidism. The size and cystic degeneration of parathroid disease are two common factors decreasing MIBI reliability, and thyroid nodule is additional source leading to false-positive results.
