Efficiency of 99Tcm-sestamibi in diagnosis of parathyroid diseases with primary hyperparathyroidism
10.3760/cma.j.issn.1673-0860.2015.02.007
- VernacularTitle:99Tcm-甲氧基异丁基异腈显像在104例原发性甲状旁腺功能亢进患者诊断中的应用
- Author:
Bojun WEI
1
;
Hong SHEN
;
Guansheng TONG
;
Rengui WANG
;
Hong CHANG
Author Information
1. 100038,首都医科大学附属北京世纪坛医院耳鼻咽喉头颈外科
- Keywords:
Hyperparathyroidism;
Technetium Tc 99m sestamibi;
Parathyroidectomy
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2015;50(2):123-126
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficiency of 99Tcm-sestamibi (MIBI) in the diagnosis of parathyroid diseases with primary hyperparathyroidism.Methods One hundred and four cases with primary hyperparathyroidism underwent MIBI and parathyroidectomy between May 2010 to November 2013 were reviewed.With MIBI,single adenoma was found in 91 cases,two adenomas in 5 cases,carcinoma and hyperplasia in 3 cases respectively.Primary hyperparathyroidism was diagnosed based on the associated symptoms and signs in 93 patients,while it was indicated in 11 asymptomatic patients due to the presence of hypercalcemia in health examination.Parathroid hormone levels ranged from 98 to 2 800 ng/L,and serum calcium levels were between 2.56-4.23 mmol/L.Results The sensitivity of MIBI for total diseased parntyroids was 84.0％ (100/119),and that for parathyroid adenoma,parnthyroid carcinoma,atypical adenoma and primary parathyroid hyperplasia was 87.1％ (88/101),3/3,2/2 and 7/13,respectively.Conclusions MIBI is efficient in the diagnosis of parathyroid diseases with primary hyperparathyroidism.The size and cystic degeneration of parathroid disease are two common factors decreasing MIBI reliability,and thyroid nodule is additional source leading to false-positive results.
