Distribution and prognostic significance of tumor-infiltrating mast cells in nasopharyngeal carcinoma
10.3760/cma.j.issn.1673-0860.2015.04.009
- VernacularTitle:肿瘤浸润肥大细胞在鼻咽癌中的分布及预后相关性研究
- Author:
Xiaomei CHEN
1
;
Xiangping LI
;
Feipeng ZHAO
;
Haoran HUANG
;
Juan LU
;
Xiong LIU
Author Information
1. 南方医科大学南方医院耳鼻咽喉科
- Keywords:
Nasopharyngeal neoplasms;
Neoplasm invasiveness;
Mast cells;
Neoplasm staging;
prognosis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2015;50(4):306-311
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the infiltration and prognostic significance of tumor-infiltrating mast cells (TIMs) in nasopharyngeal carcinoma (NPC).Methods Immunohistochemistry for tryptase was performed on 154 NPC specimens.The median value of TIM density was used as a cutoff point to separate the patient cohort into two groups with either low or high TIM infiltration.The associations between TIM and clinicopathological factors were analyzed by Mann-Whitney U text.Survival curves were plotted according to the Kaplan-Meier method.Univariate and multivariate analyses were performed using the Log-rank test and the Cox proportional hazard models,respectively.P ＜ 0.05 was considered statistically significant.All statistical analyses were conducted using SPSS 13.0.Results TIM was mainly in the stroma of NPC and detected in all specimens.The median value of TIM density (25.60/high power field) was used as a cutoff point to separate the patient cohort into two groups with either low or high TIM infiltration.The density of TIM was positively correlated with N stage (Z =-2.193,P ＜ 0.05) and clinical stage (Z =-2.551,P ＜ 0.05).The 3-year overall survival (OS) and progression-free survival (PFS) of patients were 64.4％ and 55.7％ in the high TIM density group;78.3％ and 77.0％ in the low TIM density group.For survival evaluation,high density of TIM was associated with worse OS and PFS (P ＜ 0.05).Multivariate Cox regression model analysis showed TIM infiltration was an independent risk factor for both OS and PFS.Conclusions The density of TIM in NPC increased with tumor stage.High TIM infiltration was associated with poor overall survival and progression-free survival.
