Phosphodiesterase selective inhibitors and perspective discovery of new specific drugs
- Author:
Phan Van Dao
- Publication Type:Journal Article
- Keywords:
drug
- MeSH:
Pharmaceutical Preparations;
antagonists & inhibitors
- From:Journal of Medical Research
1998;7(3):50-53
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Each PDE have isogenies (PDE 4A, PDE 4B, PDE 4C, and PDE 4D), which had different level in tissues. A cell can contain one or more DPE type. When agent (or drug) specifically and inhibited isoenzym, it will have specific effect on proteinkinase. The PDE4 and PDE3/4 compound inhibitive drugs have effects at the same time to relax trachea and anti-inflammatory. Viagra is PDE5 selective inhibitor, more important than PDE 2-3-4 with 1000 times, PDE 1 with 80 times, PDE 6 and PDE 7 with 10 times. This agent have many in vessels and cavernosum corpus. It plays role of break dow GMPv, but it depends on NO.
