Advance in molecular genetic research on primary congenital glaucoma.
10.3760/cma.j.issn.1003-9406.2016.02.029
- Author:
Xiulan LI
1
;
Haotian LIU
;
Dingding ZHANG
Author Information
1. Zunyi Medical University, Zunyi, Guizhou 563000, China. zdd25@sina.com.
- Publication Type:Journal Article
- MeSH:
Animals;
DNA Mutational Analysis;
Genetic Testing;
Glaucoma;
genetics;
Humans
- From:
Chinese Journal of Medical Genetics
2016;33(2):256-260
- CountryChina
- Language:Chinese
-
Abstract:
Primary congenital glaucoma (PCG) is one of the major diseases causing blindness in children, but its pathogenesis has remained unclear. Genetic factors play an important role in the pathogenesis of PCG. Molecular genetics of candidate genes such as CYP1B1, MYOC, LTBP2 and FOXC1 has so far been explored, but no disease-causing gene has been identified. Molecular genetic research on PCG including candidate gene screening and research strategies are reviewed here.
