Association of polymorphisms of miRNA biogenesis related genes DICER and DROSHA with azoospermia.
- Author:
Mei FU
1
;
Kehui XU
;
Junjie YE
;
Wenming XU
Author Information
- Publication Type:Journal Article
- MeSH: Azoospermia; genetics; DEAD-box RNA Helicases; genetics; Genotype; Humans; Male; MicroRNAs; genetics; Polymorphism, Single Nucleotide; Ribonuclease III; genetics
- From: Chinese Journal of Medical Genetics 2016;33(3):365-368
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of polymorphisms of miRNA biogenesis related genes DICER and DROSHA with azoospermia.
METHODSFor 330 patients with primary azoospermia and 282 fertile male controls, single nucleotide polymorphisms (SNPs) of DICER rs3742330 and DROSHA rs10719 were determined with a restriction fragment length polymorphism (RFLP) method.
RESULTSFor the SNP rs3742330, the frequency of A allele was higher among azoospermia patients compared with the controls (72.0% vs.64.4%, P=0.004), and so was the frequency of AA genotype (53.0% vs. 41.8%, P=0.027, OR=1.829, 95%CI: 1.071-3.124). On the other hand, the allelic and genotypic frequencies of rs10719 did not differ between the two groups (all P > 0.05).
CONCLUSIONPolymorphisms of rs3742330 of the DICER gene, particularly the AA genotype, may be associated with azoospermia.
