Risk factors of intrahepatic cholangiocarcinoma: a case-control study.
- Author:
Hua-bang ZHOU
1
;
Qin-rong XU
;
Hui WANG
;
Dong-xun ZHOU
;
Hao WANG
;
Qing WANG
;
Shan-shan ZHOU
;
Qian-qian TU
;
Zheng-qin SUN
;
Li AI
;
Meng-chao WU
;
He-ping HU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Bile Duct Neoplasms; epidemiology; etiology; Bile Ducts, Intrahepatic; Case-Control Studies; Cholangiocarcinoma; epidemiology; etiology; Cholelithiasis; complications; epidemiology; Female; Hepatitis B; complications; epidemiology; Hepatitis B Surface Antigens; blood; Hepatitis B e Antigens; blood; Humans; Liver Cirrhosis; complications; epidemiology; Liver Diseases; complications; epidemiology; Logistic Models; Male; Middle Aged; Odds Ratio; Risk Factors
- From: Chinese Journal of Hepatology 2009;17(12):935-939
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the potential risk factors of intrahepatic cholangiocarcinoma (ICC) in China.
METHODA case-control study including 317 patients with pathologically confirmed ICC and 634 healthy individuals was conducted. The cases and controls were matched in age, sex and inhabitancy. Data were statistically analyzed by Chi-square test and conditional logistic regression.
RESULTSUnivariate analysis showed significant difference in HBsAg seropositivity, liver cirrhosis, hepatolithiasis, choledocholithiasis and schistosomiasis between ICC patients and healthy controls (P < 0.05). Multivariate analysis confirmed that HBsAg seropositivity, liver cirrhosis, hepatolithiasis and hepatic schistosomiasis were associated with ICC, and their adjusted odds ratio (95% confidence interval) were 10.265 (6.676-15.783), 13.101 (5.265-32.604), 18.242 (3.580-92.958), 18.435 (1.930-176.082), 15.102 (4.607-49.499) and 11.820 (3.522-39.668), respectively. The incidence of hepatic cyst, cholecystolithiasis, hepatic hemangioma, fatty liver, diabetes mellitus, smoking and drinking were not significantly different between ICC patients and controls.
CONCLUSIONSThe HBV infection, liver cirrhosis, hepatolithiasis and hepatic schistosomiasis may be the risk factors for ICC in China.
