Clinical significance of liver function and autoantibodies in patients with acute or chronic drug-induced liver injury.
- Author:
Yan-Min LIU
1
;
Hui-Ping YAN
;
Ying HAN
;
Li-Jie ZHANG
;
Yan LIU
;
Hui-Yu LIAO
;
Yi-Sen CHEN
;
Yun-Li HUANG
;
Guo-Qing ZHAO
;
Hui-Guo DING
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Adult; Antibodies, Antinuclear; blood; Autoantibodies; blood; Chemical and Drug Induced Liver Injury; blood; diagnosis; immunology; Diagnosis, Differential; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Liver; pathology; physiopathology; Liver Function Tests; Male; Microsomes; immunology; Middle Aged; Muscle, Smooth; immunology
- From: Chinese Journal of Hepatology 2010;18(1):37-40
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinical significance of liver function and autoantibodies in patients with acute or chronic drug-induced liver injury.
METHODS51 patients with drug-induced liver injury were divided into acute drug induced liver injury group and chronic drug induced liver injury group, liver function and autoantibodies were compared between these two groups.
RESULTSThere was no significant difference (P more than 0.05) in alanine aminotransferase [(412.1+/-387.5) U/L and (376.0+/-319.7) U/L], aspartate aminotransferase [(352.5+/-457.9) U/L and (198.8+/-142.7) U/L], total bilirubin [(109.7+/-104.80)micromol/L and(102.4+/-135.7)micromol/L], direct bilirubin [(66.4+/-73.3)micromol/L and (61.2+/-72.1)micromol/L], alkaline phosphatase [(133.4+/-50.1) U/L and (147.4+/-97.3) U/L], gamma-glutamyltransferase [(139.9+/-134.1) U/L and (180.6+/-227.9) U/L], and albumin [(41.3+/-4.9) g/L and (39.8+/-5.3)g/L] between these two groups, however, the level of globulin [(25.1+/-5.3) g/L and (28.6+/-5.1) g/L] was significantly different between these two groups (P less than 0.05). The titers of Anti-nuclear antibody (ANA) and smooth muscle antibody (SMA) were less than or equal to 1:320 in patients with acute drug induced liver injury. The titers of ANA, antimitochondrial antibody (AMA), and SMA were more than or equal to 1:320 in most of the patients with chronic drug induced liver injury.
CONCLUSIONLiver function has no value in the diagnosis of acute or chronic drug induced liver injury. High titer autoantibodies are found in patients with chronic drug induced liver injury.
