Sample size requirements for association studies on gene-gene interaction in case-control study.
- Author:
Zhi-ping WANG
1
;
Hui-qing LI
Author Information
- Publication Type:Journal Article
- MeSH: Case-Control Studies; Gene Frequency; Genetic Markers; genetics; Genetic Predisposition to Disease; genetics; Genotype; Humans; Logistic Models; Models, Genetic; Quantitative Trait, Heritable; Research Design; Risk Factors; Sample Size; Sensitivity and Specificity
- From: Chinese Journal of Epidemiology 2004;25(7):623-626
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESample size requirements for association studies on gene-gene interaction in case-control study.
METHODSSelecting different parameters (such as inheritance mode, susceptibility frequency, frequency of allele for disease, OR of gene main effect) and infilling them into QUANTO software based on conditional logistic regression mode.
RESULTS(1) The main parameters influencing the sample size requirements were the levels of interaction between genes and the susceptibility frequency. The numbers of sample were the same between recessive and dominant when susceptibility frequency were the same. (2) Sample size for testing of gene-gene interaction was different from that for testing of genetic effects.
CONCLUSIONIt was convenient to use the numbers of sample size from the results for gene-gene interaction in case-control study.
