Significance of p53 gene mutation and P53 protein expression abnormality on the prognosis of esophageal cancer: a meta-analysis study.
- Author:
Xiao-li WANG
1
;
Chun-mei ZHANG
;
Lü-yuan SHI
;
Hong-ping YU
;
Shun-Qing XU
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Squamous Cell; genetics; metabolism; Esophageal Neoplasms; genetics; metabolism; Female; Genes, p53; genetics; Humans; Male; Mutation; Prognosis; Tumor Suppressor Protein p53; biosynthesis; genetics
- From: Chinese Journal of Epidemiology 2004;25(9):769-774
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the prognostic significance of p53 mutation and P53 protein expression abnormality among esophageal cancer.
METHODSThe results of 27 random controlled trials from 1990 to 2003 were analyzed by meta-analysis method. The overall positive rate of p53 was 52.9% among the cumulative 2174 cases. Relative hazard (RH) was applied to evaluate the risk of disease and all data were analyzed by Dersimonian-Laird method.
RESULTSThe analysis for homogeneity (q statistics test) showed that all eligible studies were with heterogeneity (q = 59.88, P < 0.005). The combined RH was 2.07 and 95% confidence interval was 1.58-2.70.
CONCLUSIONFindings showed that p53 was a poor prognosis biomarker for esophageal cancer gene diagnosis but might benefit to the strategy of treatment.
