Meta-analysis on the relationship between tobacco smoking, alcohol drinking and p53 alteration in cases with esophageal carcinoma.
- Author:
Bo WANG
1
;
Yan ZHANG
;
De-zhong XU
;
An-hui WANG
;
Lei ZHANG
;
Chang-sheng SUN
;
Liang-shou LI
Author Information
- Publication Type:Journal Article
- MeSH: Alcohol Drinking; Esophageal Neoplasms; etiology; genetics; Female; Genes, p53; genetics; Humans; Male; Mutation; Risk Factors; Smoking; adverse effects; Tumor Suppressor Protein p53; biosynthesis; genetics
- From: Chinese Journal of Epidemiology 2004;25(9):775-778
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between tobacco smoking, drinking and p53 alteration in esophageal carcinoma.
METHODSLiterature on the relationship between p53 alteration in esophageal carcinoma and tobacco smoking, drinking through Meta-analysis were reviewed.
RESULTSIn 14 selected papers related to tobacco smoking, pooled odds ratio (OR) of tobacco smoking with P53 overexpression and p53 alteration were 1.99 (95% CI: 1.30- 3.06) and 1.64 (95% CI: 1.13 - 2.37), respectively (P < 0.05). Pooled OR of tobacco smoking with p53 mutation was 1.11 (95% CI: 0.47 - 2.76) (P > 0.05). In 11 selected papers on alcohol drinking, pooled OR of drinking with P53 overexpression, p53 mutation and p53 alteration were 1.30 (95% CI: 0.83 - 2.04), 1.13 (95% CI: 0.67 - 1.90) and 1.22 (95% CI: 0.87 - 1.72) respectively (P > 0.05).
CONCLUSIONThere were significant relations between tobacco smoking and p53 alteration while there were no significant relations between alcohol drinking and p53 alteration.
