Preparation and properties of sustained-release pellets of active components from Ligusticun chuanxiong.
- Author:
Yanlong HONG
1
;
Xiao LING
;
Yi FENG
;
Desheng XU
;
Lihua CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Coumaric Acids; analysis; Delayed-Action Preparations; Ligusticum; chemistry; Technology, Pharmaceutical
- From: China Journal of Chinese Materia Medica 2011;36(4):439-442
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare sustained-release pellets of active components from Ligusticun chuanxiong by coating in the fluid-bed.
METHODThe fast-release pellets were prepared by the extrusion-spheronization process. The coating formulation was optimized with the release of ferulic acid as criteria. The micromeritic properties and drug dissolution behaviors of the prepared pellets were evaluated.
RESULTThe pellets presented perfect sphericity. The obviously sustained-release effects were shown in 12 h. The coating weight gain was the major factor impacting drug release.
CONCLUSIONThe coating pellets show the obviously sustained-release effects.
