Constituents and bioactivities of Lamiophlomis rotata.
- Author:
Yanjun HAO
1
;
Lin LI
;
Chen CHEN
;
Yuli SANG
Author Information
- Publication Type:Journal Article
- MeSH: Analgesics; pharmacology; Animals; Anti-Inflammatory Agents; pharmacology; Female; Lamiaceae; chemistry; Male; Mice; Pyrans; isolation & purification; pharmacology
- From: China Journal of Chinese Materia Medica 2011;36(4):465-467
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the chemical constituents from Lamiophlomis rotata and the bioactivities of 8-epideoxyloganic acid.
METHODThe constituents were isolated by using a combination of various chromatographic techniques including column chromatography over ployamide, silica gel and Sephadex LH-20. Structures of the isolates were identified by spectroscopic data analysis. Bioactivities were screened by using models in vivo.
RESULTFive constituents were isolated. 8-epideoxyloganic acid was isolated for the first time in L. rotata and also in lamioplomis genus. 8-epideoxyloganic acid could significantly inhibit aectic acid-induced twisting times and slower the time of homeostatsis, also inhibit xylene-induced ear edema in mice.
CONCLUSION8-epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory.
