Effects of buzhong yiqi decoction on adriamycin induced heart failure in rats.
- Author:
Na WANG
1
;
Jianping ZHANG
;
Huazhou XU
;
Guiying WANG
;
Li CHU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antibiotics, Antineoplastic; toxicity; Doxorubicin; toxicity; Drugs, Chinese Herbal; pharmacology; Heart Failure; chemically induced; prevention & control; Male; Nitric Oxide; biosynthesis; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; blood; Ventricular Function, Left; drug effects
- From: China Journal of Chinese Materia Medica 2011;36(4):508-510
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects and mechanism of Buzhong Yiqi decoction on adriamycin-induced acute myocardial injury in rats.
METHOD50 rats were randomly divided to five groups: control group, heart failure group, low dose Buzhong Yiqi decoction, high dose Buzhong Yiqi decoction and captopril group. Adriamycin was injected into the latter four groups to built a model of heart failure. Then, the effects of different doses of Buzhong Yiqi decoction on hemodynamics, cardiac tissue histological changes, antioxidant capacity and apoptosis of the damaged hearts were studied.
RESULTAdriamycin led to myocardial fiber swelling and fracture, Buzhong Yiqi decoction could reduce myocardial lesions. Buzhong Yiqi decoction could also improve heart antioxidant capacity and inhibit adriamycin-induced cardiomyocyte apoptosis.
CONCLUSIONBuzhong Yiqi decoction could significantly ease adriamycin induced heart failure in rats, and the mechanism is related to anti-oxidation and inhibiting apoptosis.
