Immunologic functions of total flavone of Epimedium of two species in Guizhou.
- Author:
Wei DENG
1
;
Minqiang ZHENG
;
Jing ZHANG
;
Cong HUANG
;
Yali ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cyclophosphamide; pharmacology; Epimedium; chemistry; Female; Flavones; pharmacology; Immunity; drug effects; Interleukin-2; blood; Male; Mice; Tumor Necrosis Factor-alpha; blood
- From: China Journal of Chinese Materia Medica 2011;36(4):511-513
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEComparative study on the immunologic functions of total flavones of Epimedium (TFE) in two species in Guizhou on CTX mice.
METHODTo set up a hypoimmunity mouse model by CTX and give TFE in 10 days, the enhancement of immunologic functions of TFE of two species were observed with the indice of the weight of body and spleen, the spleen-index, the serum level of hemolysin, TNF-alpha and IL-2.
RESULTThe spleen-index, the level of hemolysin, TNF-alpha and IL-2 of the mice decreased apparently (P < 0.01) by single ip in CTX 80 mg x kg(-1). The weight of body and spleen, the spleen-index of the mice increased, the decreased serum level of hemolysin TNF-alpha and IL-2 increased significantly (P < 0.01), by TFE of two species of 1.3, 0.65 g x kg(-1) from the mice ig.
CONCLUSIONThe TFE of two species of Epimedium in Guizhou have an obvious immune enhancement effect on the non-specific immunity and specific immunity of CTX model mice. But the immune enhancement effects of the TFE from the stem and leaves of two species of Epimedium contrast insignificantly. This indicates that in addition to ICA, there must be other bioactive components that can enhance immunity.
