OBJECTIVETo investigate the effects of Shenghua decoction on hemorheology, thrombosis and microcirculation, and explore its approach and mechanism.

METHODThe main hemorheological indexes and endothelial function were detected in acute stress blood stasis rats. The thrombus wet weight and thrombus dry weight were measured in the rat model of venous thrombosis, and the inhibitory rates in the formation of venous thrombosis were calculated. The number of paralysis or dead after 1-15 min was calculated in mice, induced by tail intravenous injection of a mixture of collagen and Epinephrine. Blood flow and the across netting were also determined on capillary vessel of uterus microcirculation.

RESULTShenghua decoction reduce blood viscidity of the rats, reduce the thrombosis of the murine, and promote the microcirculation of the uterus in rats.

CONCLUSIONShenghua decoction has the ability of blood-activating and stasis-eliminating. It also has an anti-thrombotic effect and can promote microcirculation.