Study on dispersivity of baicalin solid dispersion by vibrational spectrometry.
- Author:
Wei WANG
1
;
Xiaoman LI
;
Jinghui TIAN
;
Xinxin XI
;
Li CHENG
Author Information
- Publication Type:Journal Article
- MeSH: Flavonoids; chemistry; Solubility; Solvents; Spectrophotometry, Infrared; Spectrum Analysis, Raman; X-Ray Diffraction
- From: China Journal of Chinese Materia Medica 2011;36(5):573-575
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the dispersivity of baicalin solid dispersion by Raman spectrometry and infrared spectrometry in order to obtain a new and simple method in examining the dispersivity of solid dispersion.
METHODBaicalin solid dispersion was prepared by solvent method. The Raman spectra, infrared spectra and X-ray powder diffraction patterns of crude baicalin, PVP K30, physical mixture, solid dispersion were acquired by Raman and Fourier transform infrared spectrometers and X-ray powder diffractometry. Then the spectra were compared with each other in order to find out the differences between baicalin solid dispersion and other materials.
RESULTThe result of Raman spectrometry was that amorphous baicalin presented in the solid dispersion, which was in agreement with that of X-ray powder diffractometry.
CONCLUSIONRaman spectrometry which is fast, direct and non-destructive is an ideal method for examining the dispersivity of solid dispersion.
