Flavonoids with special B-ring from Macrothelypteris viridifrons and their anti-proliferative effects on tumor cell.
- Author:
Anhua WEI
1
;
Guanghua WU
;
Chaomei XIONG
;
Daonian ZHOU
;
Yaling CAI
;
Jinlan RUAN
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents; chemistry; pharmacology; Cell Line, Tumor; Cell Proliferation; drug effects; Ferns; chemistry; drug effects; Flavonoids; chemistry; pharmacology; HT29 Cells; Hep G2 Cells; Humans
- From: China Journal of Chinese Materia Medica 2011;36(5):582-584
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the chemical constituents of Macrothelypteris viridifrons and their anti-proliferative effects on tumor cell.
METHODThe compounds were isolated by column chromatography with silica gel, C18 reverse-phase silica gel, sephadex LH-20, and their structures were elucidated on the basis of physiochemical propertities and spectral analysis. The antitumor activities of all compounds were tested with MOLT4, Hep G2, A-549, MCF-7, HT-29, PC-3 tumor cell lines.
RESULTFive compounds were isolated and identified as protoapigenone (1), protoapigenin (2), protoapigenin-4'-O-beta-D-glucopyanoside (3), 5,7-dihydroxy-2-(1,2-isopropyldioxy-4-oxo-cyclohex-5-enyl) -chromen-4-one (4), 5,7-dihydroxy-2-(1-hydroxy-2,6-dimethoxy-cyclohex-4-oxo) -chromen-4-one (5), respectively.
CONCLUSIONAll compounds were obtained from this plant for the first time. Compounds 1, 4 and 5 showed strong anti-proliferative effects on six tumor cells, which were in concentration-dependent manner.
