Studies on anti-tumor metastatic constituents from Ardisia Crenata.
- Author:
Xue WANG
1
;
Shengan TANG
;
Huiyuan ZHAI
;
Hongquan DUAN
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents; pharmacology; therapeutic use; Ardisia; chemistry; Cell Line, Tumor; Cell Proliferation; drug effects; Drugs, Chinese Herbal; pharmacology; therapeutic use; Humans; Neoplasm Metastasis; drug therapy
- From: China Journal of Chinese Materia Medica 2011;36(7):881-885
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the anti-tumor metastatic constituents from Ardisia Crenata.
METHODChemical constituents were isolated and purified by repeated column chromatography( silica gel, Toyopearl HW40C and preparative HPLC). Their structures were elucidated on the basis of spectral data analysis. The anti-tumor metastasis assay was applied to evaluate the isolated compounds of their activities.
RESULTNine compounds(1-9) were isolated and their structures were identified by comparison of their spectral data with literature values as follows: 5-hydroxymethyl-2-furalclehyde(1), ethyl-beta-D-fructopyranoside(2), syringic acid(3), n-butyl-beta-D-fructofuranoside(4), n-butyl-alpha-D-fructofuranoside(5), methyl-alpha-D-fructofuranoside(6), (+)-bergenin(7), ardisiacrispins B(8), asperuloside acid(9). The isolated compounds(1-9) showed positive anti-tumor metastatic activities, and compounds 1, 5, and 8 showed significant anti-tumor metastatic activities. At the concentration of 0.8 mg x L(-1), compound 5 revealed the value of metastatic inhibition ratio on MDA-MB-231 was 93.8%.
CONCLUSIONCompounds 2-6 and 9 were isolated from this plant for the first time. compounds 1, 5 and 8 showed significant anti-tumor metastatic activities.
