Association of L-selectin gene polymorphism with susceptibility to coronary heart disease.
- Author:
Zun-en XIA
1
;
Yan LI
;
Kai-hua MING
;
Xiao-quan XIONG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Coronary Disease; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; genetics; Genotype; Humans; L-Selectin; genetics; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; genetics
- From: Chinese Journal of Medical Genetics 2007;24(2):173-176
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the possible association between L-selectin gene P213S polymorphism and coronary heart disease (CHD) in Chinese population.
METHODSIn total 212 CHD patients diagnosed by angiography and 230 healthy controls were studied. The genotype and allele frequencies of L-selectin gene polymorphism were assayed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
RESULTSThe frequency of the L-selectin gene 213P allele in CHD patients was significantly higher than that in the control group (77.59% vs 69.35%, P=0.006). Compared with the SS genotype, PP homozygote had a significantly increased CHD risk (OR=2.70 and OR=2.15 using unadjusted and adjusted Logistic regression models, respectively). No association was found between the severity of CHD and the Lselectin gene P213S polymorphism
CONCLUSIONOur findings suggest that L-selectin gene 213P mutant allele might contribute to susceptibility of Chinese individuals to contract CHD.
