Study on the vertical transmission of Y chromosome microdeletions from father to son.

Author: Xiao-bin ZHU ¹ ; Zhen LI ; An-liang GUO ; Xiao-rong CAO ; Yong LIU ; Dong-ming GONG ; Yi-xin WANG
Author Information

1. Renji Hospital, Shanghai Jiaotong University, Shanghai, 200001 PR China.
Publication Type:Journal Article
MeSH: Adult; Aged; Azoospermia; genetics; Chromosome Deletion; Chromosomes, Human, Y; genetics; Family Health; Female; Humans; Infertility, Male; genetics; Male; Middle Aged; Pedigree; Young Adult
From: Chinese Journal of Medical Genetics 2007;24(2):203-205
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo analyze the Y chromosome microdeletions in the family of the infertile male and to study on the vertical transmission of Y chromosome microdeletions from father to son.
METHODSThe peripheral blood of infertile patients' family male members was extracted and analyzed with modified multiplex PCR. The infertile family tree was drawn according to the results.
RESULTSTwo cases in twelve investigated families had azoospermia factor (AZFc) microdeletion heredity. The others had no heredity.
CONCLUSIONAZFc microdeletion of the Y chromosome can be transmitted to the male offspring naturally,and the same deletion can result in different phenotypes in different individuals.