Study on relationship between polymorphism sites of TIM4 and allergic asthma in the population of Han nationality from Hubei province of China.
- Author:
Yi-ping XIA
1
;
Tian-pen CUI
;
Jian-min WU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Asian Continental Ancestry Group; genetics; Asthma; ethnology; genetics; Child; Child, Preschool; China; Female; Gene Frequency; Genotype; Humans; Infant; Male; Membrane Proteins; genetics; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; genetics; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; genetics; Young Adult
- From: Chinese Journal of Medical Genetics 2007;24(2):213-216
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate two single nucleotide polymorphism sites of T cell immunoglobulin domain and mucin domain protein-4 (TIM4) and to detect their relationship with allergic asthma in a population of Hans from Hubei province of China.
METHODSThe polymorphisms (8570G > A and 11515C > A) were detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 145 cases of allergic asthma and 130 healthy controls. The genotype and allele frequencies were calculated and analyzed.
RESULTSThe genotype frequencies of GG, GA and AA in 8570G > A polymorphism were 0.985, 0.015 and 0 respectively in the healthy population and 0.931, 0.069 and 0 respectively in the allergic asthma population. There was significant difference in genotype and allele frequencies between the allergic asthma patients and control subjects (P=0. 030, P=0.032). The polymorphism of 11515C>o A was not detected.
CONCLUSIONThe polymorphism of 8570G > A in TIM4 may be associated with allergic asthma in the population of Han nationality from Hubei province of China.
