ssociation of HLA class I and II alleles with generalized vitiligo in Chinese Hans in north China.
- Author:
Jun WANG
1
;
Yu-ming ZHAO
;
Yan WANG
;
Yi XIAO
;
Ya-kun WANG
;
Hong-duo CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Alleles; Asian Continental Ancestry Group; genetics; China; Female; Gene Frequency; Genes, MHC Class I; genetics; Genes, MHC Class II; genetics; Genotype; Humans; Male; Middle Aged; Vitiligo; ethnology; genetics
- From: Chinese Journal of Medical Genetics 2007;24(2):221-223
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of HLA class I and II alleles with generalized vitiligo in ethnic Han Chinese in north China.
METHODSBy employing polymerase chain reaction sequence-specific primer (PCR-SSP) procedure 34 generalized vitiligo patients in north China were studied for HLA I and II alleles and were compared with 102 healthy controls.
RESULTSThe allelic frequencies of HLA-A*30, Cw*06, DRB1*07, and DQB1*0201 were increased significantly in generalized vitiligo and especially in the patients without family history compared with the controls.
CONCLUSIONThese alleles positively associated with generalized vitiligo in Chinese Han patients in north China, might provide clues to reveal the susceptibility gene(s) of vitiligo in Chinese and as well as the immunnogenetic mechanisms of disease.
