Study on the distribution of Y chromosome haplogroups in Sichuan Han population.

Ming-yi MA; Yuan YANG; Cui-ying XIAO; Si-zhong ZHANG

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Study on the distribution of Y chromosome haplogroups in Sichuan Han population.

Author: Ming-yi MA ¹ ; Yuan YANG ; Cui-ying XIAO ; Si-zhong ZHANG
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1. Department of Medical Genetics, West China Hospital, Sichuan University, Division of Human Morbids Genomics, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan, 610041 PR China.
Publication Type:Journal Article
MeSH: Asian Continental Ancestry Group; genetics; China; ethnology; Chromosomes, Human, Y; genetics; Electrophoresis, Polyacrylamide Gel; Ethnic Groups; genetics; Genetic Predisposition to Disease; ethnology; Haplotypes; genetics; Humans; Male; Mutation
From: Chinese Journal of Medical Genetics 2007;24(3):261-265
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the distribution characteristics of Y chromosome haplogroups in Sichuan Han population.
METHODSUsing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), denatured high performance liquid chromatography (DHPLC) and DNA sequencing methods, 18 Y-chromosome bialletic markers were detected to type Y chromosome haplogroups in 341 unselected men from Sichuan Han population.
RESULTSA total of 14 haplogroups were observed, in which haplogroups H2 and H4 were identified for the first time in Sichuan population, and haplogroups H14 and N* were found firstly in Chinese. There was a significant frequency difference of Y haplogroups between Sichuan Han population and Southern Han population.
CONCLUSIONMore comprehensive frequency distribution data of Y chromosome haplogroups are obtained in Sichuan Han population, which would be helpful for understanding the association of Y chromosome background and the susceptibility to male specific diseases such as spermatogenic failure, prostate cancer, testical cancer and so on in present population.