Association mapping of schizophrenia loci on chromosome 1 by use of pooled DNA genomic screening in eastern Shandong peninsula.
- Author:
Gang CHEN
1
;
Xiao-yan WEN
;
Hai-ning ZHU
;
Ran WEI
;
Peng ZHOU
;
Meng LUAN
;
Chun-yi GAO
;
Jian-ping ZHU
;
Zheng WENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Case-Control Studies; China; Chromosome Mapping; Chromosomes, Human, Pair 1; genetics; DNA; genetics; Female; Genomics; Humans; Male; Microsatellite Repeats; genetics; Schizophrenia; genetics; pathology
- From: Chinese Journal of Medical Genetics 2007;24(3):288-292
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo find out association mapping of loci related to schizophrenia on chromosome 1 with microsatellite markers in DNA pooling samples from schizophrenic cases and normal controls in Shandong peninsula.
METHODSA total of 31 microsatellite markers on chromosome 1 spaced at approximately 10 cM were scanned to two separated DNA pooling samples consisting of 119 schizophrenic cases and 119 normal controls respectively. Statistic analysis was performed by Chi-square test method to compare the difference between the ratio of each allele between the two pooling samples.
RESULTSSignificant statistic difference was found at D1S2878 between cases and controls, and P< 0.01 at this loci.
CONCLUSIOND1S2878 locus on chromosome 1 associates with schizophrenia in Shandong peninsula. Fine mapping and searching for candidate genes are warranted in this region.
