The association of TGF beta1 and AT1R gene polymorphisms with hereditary susceptibility and clinical phenotype of HBV-induced liver cirrhosis.
- Author:
Hua LI
1
;
Hong-lei WU
;
Hui LV
;
Hong-shan WEI
;
Hong-bo WANG
;
Pei-lin WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alleles; Case-Control Studies; Female; Genetic Predisposition to Disease; Genotype; Hepatitis B; complications; genetics; Humans; Liver Cirrhosis; genetics; virology; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Receptor, Angiotensin, Type 1; genetics; Transforming Growth Factor beta1; genetics
- From: Chinese Journal of Medical Genetics 2007;24(3):298-301
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of TGF beta1 and AT1R gene polymorphisms with hereditary susceptibility and clinical phenotype of HBV-induced liver cirrhosis.
METHODSPeripheral blood samples were collected from 102 patients with HBV-induced liver cirrhosis and 106 healthy blood donors. The polymorphisms of the promoter site -509C/T of TGF beta1 and 1166A/C of AT1R gene were determined by PCR-RFLP.
RESULTSThe frequency of the homozygote CC of -509C/T of TGF beta1 gene in the group of liver cirrhosis was higher than that the control group (P<0.05); and the frequency rate of homozygote CC was higher in group C than in group A and group B of liver cirrhosis (P<0.05), but there was no significant difference in allele frequency among these group (P>0.05). There was no significant difference in genotypes and allele frequency of AT1R gene 1166A/C between the liver cirrhosis group and the control group (P>0.05).
CONCLUSIONThe polymorphism of the promoter site -509C/T of TGF beta1 gene is associated with hereditary susceptibility to liver cirrhosis and severity of HBV-induced liver cirrhosis; the polymorphism of AT1R gene 1166A/C is not associated with hereditary susceptibility to HBV-induced liver cirrhosis.
