Distribution characters and linkage disequilibrium analysis of APOM gene polymorphisms in Han population of North China.
- Author:
Xiu-jie HAN
1
;
Jian-ping JIA
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Apolipoproteins; genetics; Apolipoproteins M; Asian Continental Ancestry Group; genetics; China; Ethnic Groups; genetics; Female; Humans; Introns; genetics; Linkage Disequilibrium; Lipocalins; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide
- From: Chinese Journal of Medical Genetics 2007;24(3):350-353
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the distribution characters and linkage disequilibrium of apolipoprotein M gene (APOM) polymorphisms in Han population of North China.
METHODSThe single nucleotide polymorphisms (SNPs) in six exons and five introns of APOM gene of 330 normal subjects in Han population of North China were detected by PCR-restriction fragment length polymorphism and DNA sequencing analysis.
RESULTSThree SNPs in Han Chinese were found, including rs805264 of intron 1, rs707922 and rs707921 of intron 5 of APOM gene. The frequency distribution of these SNPs was different among different races and territory. In addition, linkage disequilibrium among the SNPs of rs805264, rs707922 and rs707921 of APOM gene was found and A-T-A and G-G-C were predominant haplotypes.
CONCLUSIONThere is apparent linkage disequilibrium among SNPs of APOM gene in Han population of North China.
