389A/G polymorphism of the human beta1-adrenergic receptor in patients with acute myocardial infarction.
- Author:
Yan-li SONG
1
;
Xian-zheng WU
;
Gang GUO
;
Hai-xia ZHANG
;
Yi-qing YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; genetics; Genotype; Humans; Hyperlipidemias; complications; Hypertension; complications; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; etiology; genetics; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; genetics; Receptors, Adrenergic, beta-1; genetics; Risk Factors; Smoking; adverse effects
- From: Chinese Journal of Medical Genetics 2007;24(4):422-424
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relation between the 389A/G polymorphism in the human beta 1-adrenergic receptor and acute myocardial infarction (AMI).
METHODSPolymerase chain reaction amplification and restriction fragment length polymorphism analysis were used to detect the genotypes of 150 patients with AMI and 150 age- and sex- matched control subjects, and relative clinical data were obtained. A case-control study and multiple Logistic regression analysis were performed to assess the association between 389A/G polymorphism and AMI.
RESULTSThe distributions of the genotypes and allele frequencies were significantly different between two groups (P< 0.01). The prevalence of the A allele was significantly higher in patients with AMI than in control subjects. In the multivariate regression analysis, the 389A/G polymorphism (OR: 2.88, 95%CI: 1.70-4.88, P< 0.01), smoking(OR: 2.72, 95%CI: 1.52-4.88, P< 0.01), hyperlipidemia (OR: 2.85, 95%CI: 1.68-4.86, P< 0.01), diabetes mellitus(OR: 2.38, 95%CI: 1.27-4.47, P< 0.01) and hypertension (OR: 2.00, 95%CI: 1.62-3.45, P< 0.05) were independent risk factors of AMI.
CONCLUSIONThe 389A/G polymorphism in the human beta 1-adrenergic receptor is associated with AMI and is an independent risk factor of AMI.
