The study on the relationship between Rsa I, Alu I polymorphism of the estrogen receptor beta gene and unknown aetiology hypomenorrhea.
- Author:
Rui YUAN
1
;
Ai-wen LE
;
Li GEN
;
En-lan XIA
;
Zhen-wei YAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Binding Sites; genetics; Deoxyribonucleases, Type II Site-Specific; metabolism; Estrogen Receptor beta; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; genetics; Genotype; Humans; Menstruation Disturbances; etiology; genetics; Polymerase Chain Reaction; Polymorphism, Genetic; genetics; Polymorphism, Restriction Fragment Length; Young Adult
- From: Chinese Journal of Medical Genetics 2007;24(4):425-427
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relationship between estrogen receptor beta gene (ER beta) polymorphism and unknown aetiology hypomenorrhea in Southwestern China .
METHODSOne hundred eumenorrhea women were chosen as control group and another 100 hypomenorrhea patients as case group from Southwestern China. Restriction fragment length polymorphism (RFLP) of the Rsa I and Alu I in ER beta gene was analysed. The ER beta gene polymorphism genotype distribution in case group and control group was compared.
RESULTSR allele frequency in case and control groups was 37.5% and 48.5% respectively, the OR was 0.64 (95%CI: 0.42-0.97), P= 0.026. A allele frequency in case and control groups was 18.0% and 11.5% respectively, the OR was 1.69 (95%CI: 0.93-3.09), P= 0.07. RFLP of Rsa I and Alu I in both groups were distributed with polymorphism.
CONCLUSIONERbeta gene polymorphism has a relation with unknown aetiological hypomenorrhea. R allele may be the guard factor, and A allele may be its risk factor.
