An analysis method to apply linkage disequilibrium maps to association study.
- Author:
Cheng HU
1
;
Wei-ping JIA
;
Cong-rong WANG
;
Rong ZHANG
;
Xiao-jing MA
;
Qi-chen FANG
;
Kun-san XIANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Case-Control Studies; DNA-Binding Proteins; genetics; Diabetes Mellitus, Type 2; genetics; Female; Gene Frequency; Genome-Wide Association Study; methods; Haplotypes; Humans; Linkage Disequilibrium; Male; Polymorphism, Single Nucleotide; Pre-B-Cell Leukemia Transcription Factor 1; Proto-Oncogene Proteins; genetics; Retinoid X Receptor gamma; genetics
- From: Chinese Journal of Medical Genetics 2007;24(5):495-498
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo apply linkage disequilibrium (LD) maps to associations studies with high throughput single nucleotide polymorphisms (SNPs).
METHODSSeven hundred and fifty-four SNPs were genotyped in 160 Shanghai Chinese. LD maps were constructed in cases and controls separately. By comparing the decline of LD unit with distance between the two groups, disease susceptible loci were estimated. This method was compared with traditional analyses including LD analysis, single SNP and haplotype analyses.
RESULTSThe analysis of LD maps could detect the chromosome regions with different LD patterns between the cases and controls. The alleles and/or haplotypes frequencies of SNPs within the regions had significantly different distributions or trends of significantly different distributions.
CONCLUSIONThis method may be applied to analyze the data from association studies with high throughput SNPs genotype information.
