The population genetics study in HLA field.
- Author:
Kou-rong MIAO
1
;
Cheng-ya WANG
Author Information
1. HLA Laboratory, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210029 PR China.
- Publication Type:Journal Article
- MeSH:
Alleles;
Genetics, Population;
methods;
HLA Antigens;
genetics;
Haplotypes;
Humans;
Linkage Disequilibrium
- From:
Chinese Journal of Medical Genetics
2007;24(5):548-550
- CountryChina
- Language:Chinese
-
Abstract:
Human leukocyte antigen (HLA) is the most polymorphic genetic system found in human genome. The polymorphisms of different HLA genes and haplotypes in different ethnic and geographic populations are of high importance for investigation of their population genetic characteristics and searching for HLA matched unrelated hematopoietic stem cell transplantation donors, as well as in disease association studies. The HLA molecular genetic principals and the progress of HLA population investigation were reviewed, as well as the methods applied in the field.
