The Relationship between Recipients Age on the Development of Acute Rejection and Graft Survival in Kidney Transplantation.
- Author:
Seung Seok HAN
1
;
Seong Woo LEE
;
Jeong Myung AHN
;
Curie AHN
;
Jin Suk HAN
;
Suhnggwon KIM
;
Yon Su KIM
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. yonsukim@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Aged;
Kidney transplantation;
Survival;
Graft rejection
- MeSH:
Aged;
Graft Rejection;
Graft Survival;
Humans;
Immunosuppression;
Incidence;
Kidney;
Kidney Transplantation;
Rejection (Psychology);
Retrospective Studies;
Survival Rate;
Transplants
- From:Korean Journal of Nephrology
2008;27(5):576-583
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Previously, acute rejection (AR) episode in the elderly recipients was reported to be lower compared to that of young recipients. However, the relationship between the recipients age, incidence of AR, and graft survival has not been reevaluated recently. METHODS: Four hundred thirty-one recipients who had the first kidney transplantation were recruited, and we performed a retrospective study evaluating the incidence of AR, infectious episodes in one year, and graft and patient survival rates at 1 and 5 years. We divided recipients into 2 groups (age< 50, n=340 and age=50, n=91) and compared the outcomes. RESULTS: The incidence of AR was 18.8% in the younger group and 24.2% in the elderly group (p=NS). The incidence of infectious episodes was 24.7% in the younger group and 24.2% in the elderly group (p=NS). Five-year graft survival in the elderly was not significantly different from that in the younger group (90.8% vs. 91.8%). However, the patient survival at five year was different between the younger and the elderly groups (99.1% and 92.2%, respectively, p<0.05). CONCLUSION: Our findings suggest that recipients age would not influence the incidence of AR and graft survival. Therefore, the immunosuppression should be applied according to the conditions of recipients, not to recipients age.
