Protective effect of Jiangbaiweiyan tablet on ethanol-induced gastric mucosa injury in rats.
- Author:
Xu-chun FU
1
;
Hai-li SHAN
;
Hai-bo BAI
;
Rong HU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Drugs, Chinese Herbal; therapeutic use; Ethanol; toxicity; Female; Gastric Mucosa; drug effects; pathology; Rats; Rats, Sprague-Dawley; Stomach Ulcer; chemically induced; pathology; prevention & control; Tablets
- From: Journal of Zhejiang University. Medical sciences 2011;40(4):391-394
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of Jiangbaiweiyan tablet, a Chinese medicine compound composed of Alpinta Officinarum, Cyperus Rotundus, Bulbus Lilii and Rlindera Strychnifolia, on ethanol-induced gastric mucosa injury in rats.
METHODSAcute gastric ulcer was induced in rats with absolute ethyl alcohol. The ulcer index was used to evaluate the extent of the gastric mucosa injury.
RESULTSThe ulcer indexes of the model group, the mid-dose (1.08 g x kg(-1) x d-(-1)1) and high-dose (2.16 g x kg(-1) x d-(-1)) of Jiangbaiweiyan tablet groups were 141.58±47.43, 24.83±23.04 and 2.12±2.58, respectively (P<0.01).
CONCLUSIONJiangbaiweiyan tablet has protective effects on ethanol-induced gastric mucosa injury in rats, which may be related to anti-oxidation and enhancing tissue regeneration capacity.
