Association of thrombospondin-1 gene N700S polymorphism with coronary artery disease.
- Author:
Yu-ping SHI
1
;
Hua-lan GONG
;
Hai-bo LIU
;
Jiang SHAN
;
Geng XU
;
Jian-an WANG
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Case-Control Studies; Coronary Artery Disease; genetics; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Thrombospondin 1; genetics
- From: Journal of Zhejiang University. Medical sciences 2011;40(4):421-426
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of thrombospondin-1 (TSP- 1) gene A8831G (N700S) polymorphism with coronary artery disease (CAD).
METHODSThis study was conducted with a case-control design including 178 patients with CAD (55 AMI) and 158 healthy subjects. The TSP-1 N700S polymorphism was determined by polymerase chain reaction and restriction fragment length polymorphism analysis.
RESULTSNo significant difference of the AG genotype in CAD group and control group (1.7% compared with 0.6%, P=0.375) was detected. None of the homozygotes was detected for the G allele. The prevalence of the G allele was not significantly different between CAD group and controls (0.8% compared with 0.3%, P=0.376). No significant difference of the AG genotype in AMI group and control group (3.6% compared with 0.6%, P=0.104). The prevalence of G allele was not significantly different between AMI patients and controls (1.8% compared with 0.3%, P=0.364).
CONCLUSIONThere are TSP-1 N700S polymorphisms in Chinese Zhejiang Han people, but the TSP-1 N700S variant shows a much lower prevalence compared with Western populations and may be not a potential risk for CAD and AMI.
