Mechanism of NMDA receptor-dependent neuronal survival and neuroprotection.
- Author:
Song DO
1
;
Jian-hong LUO
;
Shuang QIU
Author Information
1. Institute of Neuroscience, College of Medicine, Zhejiang University, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Neurons;
metabolism;
physiology;
Receptors, N-Methyl-D-Aspartate;
metabolism;
physiology;
Synaptic Transmission
- From:
Journal of Zhejiang University. Medical sciences
2011;40(4):440-445
- CountryChina
- Language:Chinese
-
Abstract:
NMDA (N-methyl-D-aspartate) receptors are a subtype of glutamate receptor, and play an important role in both synaptic transmission and synaptic plasticity. When excessively excited, NMDA receptors can cause cell death in many neuropathological scenarios such as OGD (oxygen and glucose deprivation) and brain injury. However, recent studies have revealed that under the physical and some pathological conditions, NMDA receptor could promote neuronal survival and protect neurons from damage.
