Research progress on spindle assembly checkpoint gene BubR1.
- Author:
Zhao-jun CHEN
1
;
Feng LI
;
Jun YANG
Author Information
1. Zhejiang University School of Public Health, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Cell Cycle Proteins;
genetics;
metabolism;
physiology;
Chromosome Segregation;
genetics;
physiology;
Kinetochores;
metabolism;
physiology;
Mitosis;
genetics;
physiology;
Protein-Serine-Threonine Kinases;
genetics;
metabolism;
physiology;
Saccharomycetales;
genetics;
physiology;
Spindle Apparatus;
genetics;
metabolism;
physiology
- From:
Journal of Zhejiang University. Medical sciences
2011;40(4):446-450
- CountryChina
- Language:Chinese
-
Abstract:
BubR1 gene is a homologue of the mitotic checkpoint gene Mad3 in budding yeast which is highly conserved in mammalian. BubR1 protein is a key component mediating spindle assembly checkpoint activation. BubR1 safeguards accurate chromosome segregation during cell division by monitoring kinetochore-microtubule attachments and kinetochore tension. There is a dose-dependent effect between the level of BubR1 expression and the function of spindle assembly checkpoint. BubR1-deficient would lead to mitotic progression with compromised spindle assembly checkpoint because cells become progressively aneuploid. Recently, it has been reported that BubR1 also plays important roles in meiotic, DNA damage response, cancer, infertility, and early aging. This review briefly summarizes the current progresses in studies of BubR1 function.
