Anti-proliferation and chemo-sensitization effects of apigenin on human lung cancer cells.
- Author:
Huan-yu REN
1
;
Xiu-wen TANG
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents; pharmacology; Apigenin; pharmacology; Cell Line, Tumor; drug effects; Cell Proliferation; drug effects; Drug Synergism; Humans; Lung Neoplasms; pathology
- From: Journal of Zhejiang University. Medical sciences 2011;40(5):508-514
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the antitumor effect of apigenin on human lung cancer cells.
METHODSThe anti-proliferation and sensitization effects of apigenin on human lung cancer cells was accessed by counting cells after Trypan blue staining and MTS assay.
RESULTS(1) Apigenin significantly suppressed the proliferation of four types of human lung cancer cells (A549:P=0.041, H460:P=0.050, LTEP-a2:P=0.039, H292:P=0.016); (2) Apigenin significantly increased the susceptibility of human lung cancer cells to antitumor drugs (P<0.05 or P<0.01) in a synergistic way (almost all of the combination index values are less than 1).
CONCLUSIONApigenin widely inhibits cell proliferation of various lung cancer cell lines in a dose-dependent manner and the combination treatment of apigenin and antitumor drugs is very effective in human lung cancer cells, and Nrf2-ARE pathway may contribute to the mechanism.
