HIF-1 signal pathway in cellular response to hypoxia.
- Author:
Ping-ping WANG
1
;
Fan-ping KONG
;
Xue-qun CHEN
;
Ji-zeng DU
Author Information
1. Department of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Hypoxia;
physiology;
Humans;
Hypoxia-Inducible Factor 1;
metabolism;
Signal Transduction
- From:
Journal of Zhejiang University. Medical sciences
2011;40(5):559-566
- CountryChina
- Language:Chinese
-
Abstract:
HIF-1 is composed of HIF-1α and HIF-1β subunits. It promotes target genes transcription under hypoxia and plays essential roles in cell development, physiological adaptations, and pathological processes. In the past 10 years, the research on signaling pathways of HIF-1 in response to cell hypoxia stress, especially on HIF-1α-mediated gene transcription has made great progress.
