An Adult Case of Tubulointerstitial Nephritis and Uveitis Syndrome in Korea.
- Author:
Soo Min KIM
1
;
Jae Uk SONG
;
E Ryoung CHOI
;
Hee Joung CHOI
;
Jung Eun LEE
;
Ghee Young KWON
;
Woo Seong HUH
;
Yoon Goo KIM
;
Dae Joong KIM
;
Ha Young OH
Author Information
1. Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jungeun34.lee@samsung.com
- Publication Type:Case Report
- Keywords:
Tubulointerstitial nephritis;
Uveitis;
Fanconi syndrome;
Steroids
- MeSH:
Adult;
Anemia;
Anorexia;
Biopsy;
Creatinine;
Diagnosis, Differential;
Fanconi Syndrome;
Fever;
Humans;
Hypokalemia;
Hypophosphatemia;
Korea;
Mycophenolic Acid;
Nausea;
Nephritis, Interstitial;
Proteinuria;
Steroids;
Uveitis;
Weight Loss
- From:Korean Journal of Nephrology
2008;27(5):606-610
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of adult-onset tubulointerstitial nephritis and uveitis syndrome with Fanconi syndrome. A 31-year-woman presented with fever, anorexia, nausea, general weakness and weight loss for two months. Her initial laboratory findings showed anemia, high serum creatinine, hypouricemia, hypophosphatemia, hypokalemia, glucosuria, and proteinuria. She was diagnosed as having acute tubulointerstitial nephritis by renal biopsy. The etiology of tubulointerstitial nephritis was unclear. She was treated with systemic corticosteroid. Six months later and while the patient was still on systemic corticosteroid (Deflazacort 36 mg), bilateral uveitis developed. Renal function was recovered by systemic corticosteroid and mycophenolic acid. But ocular symptoms relapsed twice despite systemic corticosteroid treatment. The ocular symptoms improved after topical ophthalmic steroid drops and injection. Tubulointerstitial nephritis and uveitis syndrome should be considered in the differential diagnosis of the unexplained tubulointerstitial nephritis. And the need of the steroid treatment also should be considered in the case of adult-onset.
