Preparation of rat model of systemic inflammatory response syndrome induced by zymosan.
- Author:
Qi-yu LU
1
;
Yu-yang ZHOU
;
Jun-bo WANG
;
Lin WANG
;
Lu MENG
;
Jia-kan WENG
;
Bo YU
;
Shen QUAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Female; Interleukin-10; blood; Interleukin-6; blood; Male; Paraffin; toxicity; Rats; Rats, Sprague-Dawley; Systemic Inflammatory Response Syndrome; blood; chemically induced; pathology; Tumor Necrosis Factor-alpha; blood; Viscera; pathology; Zymosan; toxicity
- From: Journal of Zhejiang University. Medical sciences 2011;40(6):641-646
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish a model of systemic inflammatory response syndrome (SIRS) in rats.
METHODSSD rats were intraperitoneally injected with different concentrations of zymosan suspension. The general status, temperature, white cell count, tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), interleukin-10 (IL-10) and the pathological changes of main organs were examined.
RESULTSThe conditions of rats receiving zymosan doses of 750 mg/kg and 1000 mg/kg were consistent with the criteria of SIRS model; however, the mortality of 1000 mg/kg group was higher than that of 750 mg/kg group.
CONCLUSIONThe rat model of systemic inflammatory response syndrome has been successfully induced.
