Research progress on nicotinamide phosphoribosyl transferase involved in aging and age-related diseases.
- Author:
Feng WANG
1
;
Wei-ping ZHANG
Author Information
1. Department of Pharmacology, College of Medicine, Zhejiang University, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Aging;
metabolism;
physiology;
Animals;
Humans;
Neoplasms;
metabolism;
physiopathology;
Nerve Degeneration;
metabolism;
physiopathology;
Nicotinamide Phosphoribosyltransferase;
metabolism;
physiology
- From:
Journal of Zhejiang University. Medical sciences
2011;40(6):680-684
- CountryChina
- Language:Chinese
-
Abstract:
Nicotinamide phosphoribosyl transferase (NAMPT) is the key enzyme for the synthesis of nicotinamide adenine dinucleotide (NAD), and also serves as a cytokine in mammalian cells. NAMPT is known to participate in biological responses such as glucose metabolism, inflammatory response and stress. Recent studies have revealed that NAMPT is closely associated with aging and age-related diseases such as diabetes, obesity, cancers, neuronal degeneration and cardiovascular diseases. Research on NAMPT may provide insight on prevention and treatment of related diseases.
