Effects of sea cucumber cerebroside and its long-chain base on lipid and glucose metabolism in obese mice.
- Author:
Zhuang GAO
1
;
Xin ZHOU
;
Xiao-qian HU
;
Chang-hu XUE
;
Jie XU
;
Yu-ming WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Glucose; metabolism; Cerebrosides; pharmacology; Lipid Metabolism; Lipids; blood; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; blood; drug therapy; Sea Cucumbers; chemistry
- From: Journal of Zhejiang University. Medical sciences 2012;41(1):60-64
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of sea cucumber cerebroside(SCC) and its long-chain base(LCB) on lipid and glucose metabolism in obese mice.
METHODSThe mouse obese model was established by feeding high fat diet. The mice were randomly assigned to 4 groups: control group, model group, SCC group and LCB group. After 4 weeks, the glucose tolerance test was undertaken. After 5 weeks, the body fat content, organic indexes, serum lipid level, glycemic index and liver lipid level were determined.
RESULTSCompared with the model group, the glucose tolerance in the SCC group and LCB group was ameliorated significantly (P<0.01, P<0.05); glycemic index (P<0.01, P<0.01), the weight of adipose tissue (P<0.05, P<0.01) and the hepatic TG were reduced significantly (P<0.05, P<0.05).
CONCLUSIONSea cucumber cerebroside and its long-chain base can improve the glucose and lipid metabolism in obese mice.
