A Case of Rapidly Progressive Glomerulonephritis in a Hepatitis B Virus Carrier Successfully Treated with High dose Immunosuppressive Therapy and Prophylactic Lamivudine.
- Author:
Jung Eun LEE
1
;
Jung Myung LEE
;
Jung Tak PARK
;
Kyu Hun CHOI
;
Ho Yung LEE
;
Dae Suk HAN
;
Hyeun Joo JEONG
;
Beom Seok KIM
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. docbsk@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Lamivudine;
Hepatitis B virus;
Rapidly progressive glomerulonephritis
- MeSH:
Adult;
Biopsy;
Creatinine;
Cyclophosphamide;
Glomerulonephritis;
Hematuria;
Hepatitis;
Hepatitis B;
Hepatitis B Surface Antigens;
Hepatitis B virus;
Humans;
Lamivudine;
Plasmapheresis;
Proteinuria;
Steroids;
Stress, Psychological
- From:Korean Journal of Nephrology
2008;27(5):622-625
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 35-year-old man, previously hepatitis B surface antigen (HBsAg) carrier, presented with gross hematuria and heavy proteinuria that he had been suffering from for 1 month. Serum creatinine was 4.4 mg/dL. Renal biopsy showed pauci-immune crescentic glomerulonephritis. He received plasmapheresis and was treated with high-dose steroids and cyclophosphamide. Lamivudine was started for the prevention of hepatitis B virus (HBV) activation. Serum creatinine and proteinuria were ameliorated one week after the treatment. There was no sign of HBV activation after six months of treatment. We report a case of rapidly progressive glomerulonephritis in a HBV carrier successfully treated with high dose immunosuppressive therapy and prophylactic lamivudine.
