Roles of microvesicles in tumor progress and its clinical application.
- Author:
Ying-ying WU
1
;
Xiu-jin YE
Author Information
1. Center of Bone Marrow Ttransplantation, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
- Publication Type:Journal Article
- MeSH:
Cell Communication;
Cytoplasmic Vesicles;
chemistry;
physiology;
ultrastructure;
Humans;
Neoplasms;
pathology;
physiopathology;
Neoplastic Processes;
Neovascularization, Pathologic;
Tumor Microenvironment
- From:
Journal of Zhejiang University. Medical sciences
2012;41(1):105-110
- CountryChina
- Language:Chinese
-
Abstract:
Microvesicles transport special proteins, micro RNA and DNA segments, which provides new access to intercellular communication. Tumor-derived membrane microvesicles (TMV) are involved in the tumor progress by transporting tumor-derived proteins, delivering microRNA to surrounding normal cells to alter their phenotype and promoting reverse transcription to interfere gene stability and to create tumor microenvironment. TMV also play crucial roles in tumor angiogenesis and matrix degradation, which facilitates malignant cell metastasis. TMVs are also involved in escaping immunological surveillance by intensifying the function of suppressor T cell and inducing apoptosis of cytotoxic T cells. On the other hand, microvesicles carry tumor antigens and can be used for development of tumor vaccines; some new vaccines such as AEX and DEX are under early clinical trials. Circulating microRNA and DNA segments in body fluid can be a new potential biomarker for cancer diagnosis and prognosis. Purification of microvesicles needs to be further improved, which is important for identification of microvesicles and their subtypes.
