Research progress on MKP-1 in tumor drug resistance.
- Author:
Yan HAI
1
;
Xiu-wen TANG
Author Information
1. Department of Biochemistry and Genetics, Zhejiang University School of Medicine, Hangzhou 310058 China.
- Publication Type:Journal Article
- MeSH:
Drug Resistance, Neoplasm;
physiology;
Dual Specificity Phosphatase 1;
metabolism;
physiology;
Humans;
Signal Transduction
- From:
Journal of Zhejiang University. Medical sciences
2012;41(1):111-116
- CountryChina
- Language:Chinese
-
Abstract:
The main obstacle for chemotherapy is tumor drug resistance. Studying the mechanisms of drug resistance and reversing drug resistance is the key to improve the effectiveness of chemotherapy. It has been reported that MKP-1 plays an important role in tumor drug resistance. MKP-1, as a negative regulator of MAPKs, is involved in the MAPKs mediated drug resistance and is regulated by ERK and p38 signaling pathways.However, the relationship between MKP-1 and other drug resistance-related signaling pathways is not clear and requires further investigation.
