Characterization of class 1 integron gene cassettes among clinical bacteria isolated from one large hospital in northern China.

Author: Xia CHEN ¹ ; Gui Xi LI ; Hong ZHANG ; Min YUAN ; Xiao Ping HOU ; Hui Lan YU ; Juan LI
Author Information

1. State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Publication Type:Journal Article
MeSH: Bacteria; classification; genetics; isolation & purification; China; Hospitals, Public; Humans; Integrons; genetics
From: Biomedical and Environmental Sciences 2013;26(12):1003-1007
CountryChina
Language:English
Abstract: The class 1 integron and complex gene cassettes among different species of clinical isolates in northern China were characterized in this study. 383 clinical isolates were obtained from northern China, and class 1 integrons containing gene cassettes widely distributed among gram negative clinical isolates was observed. We find that the class 1 integron showed positive correlation with multidrug resistance phenotype of gram negative bacteria. In addition, we find that isolates belonged to one species harbored different types of gene cassette arrays, while same types of gene cassette arrays were observed in different species of isolates. The diversity of gene cassette arrays among the isolates indicated the complexity of multidrug resistance in clinical isolates in northern China.